NEURAL CONTROL & COORDINATION:
Neurons are structural & functional unit of neural system.
Neuron is made of Cell body, Dendron (branches: dendrites) & Axon (branches: axonites with synaptic knob).
Types of Neurons:
Types of Neurons:
- Unipolar: No Dendron. Found in embryo.
- Bipolar: One dendron. Found in retina.
- Multipolar: 2 or more dendrons. Most common.
- Myelinated: Schwann cells with a myelin sheath around axon. Gaps b/w adjacent myelin sheaths are called nodes of Ranvier.
- Non-myelinated: Schwann cells without myelin sheath.
GENERATION & CONDUCTION OF NERVE IMPULSES
- In a resting neuron, axoplasm has more K+ & –vely charged proteins and less Na+. The fluid outside the axon contains low K+ & high Na+. This forms an ionic gradient.
- Na-K pump maintains the ionic gradients. It transports 3 Na+ outwards for 2 K+ into cell. So membrane is polarized (outer +ve, inner -ve).
- Resting potential: Potential difference of resting membrane.
- If a stimulus is given, membrane at site A becomes permeable to Na+ causing rapid influx of Na+ and reversal of polarity (depolarization).
- Electrical potential difference during depolarization is called action potential (a nerve impulse).
- Action potential is conducted as current flow from site A to B and the process is repeated along the axon.
Functional junction between two neurons. It is 2 types:
Impulse reaches at axon terminal → synaptic vesicles bind on plasma membrane → release of neurotransmitter → diffuses across synaptic cleft → combine with receptors on post synaptic membrane → opening of ion channels allowing entry of ions → action potential.
A. BRAIN
a. Cerebrum:
Cochlea (organ of hearing):
Mechanism of hearing:
Pinna collects sound waves → ear canal → tympanic membrane → vibrations → to ear ossicles & oval window → perilymph in vestibular canal → scala tympani → basilar membrane → sensory hair cells press against tectorial membrane → impulse → auditory nerve → to brain → hearing.
3. NOSE (Organ of smell):
- Electrical synapse: In this, membranes of pre- & post-synaptic neurons are nearest. So impulse transmission is same as along an axon. Impulse transmission is faster than in chemical synapse.
- Chemical synapse: It has synaptic cleft between pre- & post-synaptic neuron. Presynaptic regions have Synaptic knob. They contain synaptic vesicles filled with neurotransmitters.
Impulse reaches at axon terminal → synaptic vesicles bind on plasma membrane → release of neurotransmitter → diffuses across synaptic cleft → combine with receptors on post synaptic membrane → opening of ion channels allowing entry of ions → action potential.
HUMAN NERVOUS (NEURAL) SYSTEM (CNS & PNS)
CENTRAL NEURAL SYSTEM (CNS)
A. BRAIN
- Covered by cranial meninges (outer dura mater, middle arachnoid mater and inner pia mater.
- The subarachnoid space is filled with cerebrospinal fluid (CSF).
- Conduction of impulses to and from the brain.
- Centre of spinal reflexes.
1. Forebrain (Cerebrum + Thalamus + Hypothalamus)
a. Cerebrum:
Consists of 2 Cerebral hemispheres with cerebral cortex.
3 functional areas:
- Motor area: Controls voluntary movements of muscles.
- Sensory area: Controls functioning of sense organs
- Association area: For intersensory association, memory & communication
Coordinating centre (relay station) for sensory and motor impulses.
c. Hypothalamus:
c. Hypothalamus:
Regulates temperature, thirst, hunger & emotions. Secretes hormones.
Corpora quadrigemina: 4-lobed structure- Lobes of visual reflex (2) & Lobes of auditory reflex (2)
2. Midbrain
Corpora quadrigemina: 4-lobed structure- Lobes of visual reflex (2) & Lobes of auditory reflex (2)
3. Hindbrain
3 parts:- Cerebellum: Co-ordinates muscular activities and body equilibrium.
- Pons varoli: Co-ordinates the activities of eye and ear and regulates respiration.
- Medulla oblongata: Controls respiration, cardiovascular reflexes, gastric secretions.
Amygdala + hippocampus + hypothalamus etc.
It regulates sexual behavior, motivations, emotions.
System of Cranial & spinal nerves.
PERIPHERAL NEURAL SYSTEM (PNS)
Consists of 2 parts:
1. Somatic neural system:
Relays impulses from the CNS to skeletal muscles.
2. Autonomic neural system (ANS):
Relays impulses from the CNS to skeletal muscles.
2. Autonomic neural system (ANS):
Transmits impulses from CNS to involuntary organs & smooth muscles.
Includes 2 types of nerves:
It is the rapid, involuntary and unconscious actions of body in response to a stimulus. E.g.
- Sympathetic nerves: Prepares body to cope with emergencies, stresses & dangers. It increases heartbeat, breathing rate, constricts arteries and elevates BP.
- Parasympathetic nerves: Returns the body to a resting state and slows down heartbeat, dilates arteries, lowers BP etc.
REFLEX ACTION
It is the rapid, involuntary and unconscious actions of body in response to a stimulus. E.g.
- Withdrawal of hand when it touches a hot object.
- Knee jerk phenomenon.
- Pathway of impulses in a reflex action.
- Receptor organ → Sensory (afferent) neuron → Interneuron → Motor (efferent) neuron → effector organ (muscle/gland).
SENSE ORGANS
1. EYE
- Eyeball has 3 layers: outer Sclera, middle Choroid (blood vessels) & inner Retina.
- Cornea: Anterior transparent portion of sclera.
- Iris: Pigmented portion of the eye.
- Pupil: Central opening of iris. It regulates the amount of light entering the eye.
- Retina has 3 layers- inner ganglion cells, middle bipolar cells & outer photoreceptor cells.
- Photoreceptor cells are 2 types: rods and cones. They contain photosensitive proteins (photopigments).
- Cone cells: For Daylight (photopic) vision & colour vision. They contain photopsin.
- Rod cells: For Twilight (scotopic) vision. They contain rhodopsin. It contains a derivative of Vitamin A.
- Blind spot: Region where there are no photoreceptor cells.
- Macula lutea: Yellowish pigmented spot with a central pit (fovea). In fovea, only cones are seen. Greatest visual acuity.
- Space between cornea & lens (aqueous chamber) contains aqueous humor.
- Space between lens and retina (vitreous chamber) contains vitreous humor.
Mechanism of vision
Light from object → cornea & lens → focus on retina → dissociation of retinal & opsin → membrane permeability changes → potential difference in photoreceptor cells → action potential in ganglion cells → impulses to optic nerves → brain → vision.
Light from object → cornea & lens → focus on retina → dissociation of retinal & opsin → membrane permeability changes → potential difference in photoreceptor cells → action potential in ganglion cells → impulses to optic nerves → brain → vision.
2. EAR
3 divisions: External ear, middle ear & inner ear.
- External ear: Consists of pinna, auditory meatus (ear canal) & tympanic membrane (ear drum).
- Middle ear: Consists of tympanic cavity and ear ossicles (Malleus, Incus & stapes). Eustachian canal connects middle ear to pharynx. It equalizes pressure on either side of the eardrum. Stapes is smallest bone of body.
- Inner ear: Consists of bony labyrinth & membranous labyrinth (cochlea & Vestibular apparatus).
- 3 semicircular canals: Each canal has an ampulla with crista ampullaris.
- Otolith organ (utricle + saccule): Consists of the receptor Macula.
Cochlea (organ of hearing):
- It has 3 canals - scala vestibula, scala media & scala tympani.
- Scala vestibula & scala media are separated by Reissner’s membrane.
- Scala media and scala tympani are separated by basilar membrane.
- Organ of Corti: Receptor organ on the basilar membrane.
Mechanism of hearing:
Pinna collects sound waves → ear canal → tympanic membrane → vibrations → to ear ossicles & oval window → perilymph in vestibular canal → scala tympani → basilar membrane → sensory hair cells press against tectorial membrane → impulse → auditory nerve → to brain → hearing.
3. NOSE (Organ of smell):
- Olfactory receptors.
- Neurons of olfactory epithelium extend into a pair of olfactory bulb.
4. TONGUE (Organ of taste):
- Primary tastes: sweet, salt, sour & bitter.
- Taste buds (Gustatoreceptors + supporting cells) are seen around the bases of taste papillae.
- Largest sense organ.
- Contains receptors for heat, cold, touch, pain & pressure.