16. DIGESTION AND ABSORPTION
II. DIGESTIVE (ASSOCIATED) GLANDS
-
They
secrete digestive juices.
- They include salivary glands,
gastric glands, intestinal glands,
pancreas & liver.
a.
Salivary glands
-
3
pairs. They are
o Parotids (2): Largest salivary gland. Seen in cheeks.
o Submaxillary/submandibular (2): Seen in lower jaw.
o Sublingual (2): Below the tongue.
- Salivary glands secrete saliva. It contains 99.5%
water, mucin (mucus), enzymes like salivary amylase (Ptyalin)
and Lysozyme
and electrolytes (Na+, K+, Cl-, HCO3-
etc).
b.
Gastric glands
Tubular glands found on the inner
wall. They consist of
a. Mucus neck cells: Secrete mucus. Mucus and bicarbonates
protect the stomach wall (mucosal epithelium) from HCl and prevents autodigestion.
b. Chief (zymogen or peptic) cells: Secrete proenzymes like pepsinogen & prorennin and some lipase.
c. Oxyntic (parietal) cells: Secrete HCl & Castle’s intrinsic factor
(for absorption of vitamin B12).
Gastric glands secrete
acidic (pH 1.8-2.0) gastric juice.
c.
Liver
- Largest
gland (1.2 - 1.5 kg). Reddish brown.
- Situated
in abdominal cavity, just below the diaphragm.
- Bilobed
(large right lobe & small left lobe). Each lobe is formed of hepatic
lobules (structural & functional units).
- A
lobule has many hepatic cells arranged as cords around a central vein. They
secrete alkaline bile juice.
- Liver
lobule is covered by Glisson’s capsule.
- Bile is transported from liver to
duodenum as follows:
Bile → hepatic duct → gallbladder
→ cystic duct → common bile duct → common
hepato-pancreatic duct → duodenum.
- Hepato-pancreatic duct is guarded by sphincter of Oddi.
- Bile has no
enzymes but contains bile pigments (bilirubin & biliverdin),
bile salts, cholesterol and phospholipids.
d.
Pancreas
-
Second
largest gland. Seen near duodenal loop.
-
It
is a cream-coloured heterocrine gland, i.e. it has both exocrine and endocrine
parts.
- The
exocrine part has a pancreatic duct that opens into
duodenum along with bile duct (hepato-pancreatic duct).
- Exocrine
part secretes alkaline pancreatic juice. It contains
inactive protease enzymes (trypsinogen, chymotrypsinogen &
procarboxypeptidases), amylases, lipases & nucleases.
e.
Intestinal glands
- Simple
tubular glands. 2 types:
1. Crypts of Lieberkuhn: Consists of mucus-secreting Goblet
cells and enzyme-secreting Paneth cells.
2. Brunner (duodenal) glands: Confined to submucosa of duodenum.
Secrete mucus only.
- Intestinal
glands secrete alkaline intestinal juice (succus entericus). It contains enzymes (maltase,
lactase, sucrase, dipeptidase, lipases, nucleotidases,
nucleosidases etc).
- The bicarbonate and mucus provide alkaline medium and protect intestinal mucosa.
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